Age effects on motor threshold

Background: rTMS is a clinically effective antidepressant treatment in elderly patients1. The brain's cortical excitability depends on thickness and the distance between coil cortex. Both coil-cortex could be affected due to atrophy occurring with age2. However, previous studies3–8 were inconsistent. Methods: This retrospective study included 129 patients major depressive disorder (MDD) recruited from 2016 2020, age 15 – 50 years (n = 61) or 51 84 68). Resting motor thresholds (RMT) measured weekly for every patient. Results: older cohort of had significantly (p-value: 0,001) higher average RMT 55 % +/- 10,9 maximal stimulation output (1,2 T) compared younger (49 6,9 %). Linear regression as continuous variable showed correlation coefficient 0,36, which again underlines apparent RMT. Conclusions: These findings support existing literature differences age. Moreover, focus patients, our results are believed contribute tolerability based relationship Conflict Interest: None Funding: Disclosures: